Title : Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice.

Pub. Date : 2009 Oct 9

PMID : 19661066






3 Functional Relationships(s)
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1 Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice. Berberine mitogen-activated protein kinase 8 Mus musculus
2 We found that berberine inhibited Th17 differentiation by activating ERK1/2 and inhibited Th1 differentiation by inhibiting p38 MAPK and JNK activation. Berberine mitogen-activated protein kinase 8 Mus musculus
3 Berberine down-regulated the activity of STAT1 and STAT4 through the suppression of p38 MAPK and JNK activation, and it controlled the stability of STAT4 through the ubiquitin-proteasome pathway. Berberine mitogen-activated protein kinase 8 Mus musculus