Pub. Date : 2009 Jul 22
PMID : 19661014
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Macrolide antibiotics like azithromycin increase lipopolysaccharide-induced IL-8 production by human gingival fibroblasts. | Azithromycin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | AZM increased PgLPS-induced IL-8 production dose-dependently, while AZM did not alter IL-6 and PGE2 productions. | Azithromycin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | However, the use of the inhibitors of cell signaling pathway failed to reveal the mechanism that AZM enhanced PgLPS-induced IL-8 production. | Azithromycin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 4 | Because AZM increased LPS-induced IL-8 production by HGFs, the possibility is considered that neutrophils may be migrated to periodontal tissue and phagocytize the periodontopathic bacteria more efficiently. | Azithromycin | C-X-C motif chemokine ligand 8 | Homo sapiens |