Title : A novel hydroxyfuroic acid compound as an insulin receptor activator. Structure and activity relationship of a prenylindole moiety to insulin receptor activation.

Pub. Date : 2009 Jul 30

PMID : 19642985






2 Functional Relationships(s)
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1 METHODS: A series of hydroxyfuroic acid compounds were synthesized and tested for their efficacies at activating human insulin receptor. 2-Furancarboxylic acid, 3-hydroxy- insulin receptor Homo sapiens
2 RESULT AND CONCLUSION: This study reports a new non-quinone DMAQ B1 derivative, a hydroxyfuroic acid compound (D-410639), which is 128 fold less cytotoxic as DMAQ B1 and as potent as compound 2, a DMAQ B1 synthetic derivative from Merck, at activating human insulin receptor. 2-Furancarboxylic acid, 3-hydroxy- insulin receptor Homo sapiens