Pub. Date : 2009 Aug 15
PMID : 19638574
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sorafenib inhibits non-small cell lung cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells. | Sorafenib | B-Raf proto-oncogene, serine/threonine kinase | Homo sapiens |
| 2 | Sorafenib is a multikinase inhibitor whose targets include B-RAF and C-RAF, both of which function in the extracellular signal-regulated kinase (ERK) signaling pathway but which also have distinct downstream targets. | Sorafenib | B-Raf proto-oncogene, serine/threonine kinase | Homo sapiens |
| 3 | The G(1) arrest induced by either C-RAF depletion or sorafenib in cells with mutant KRAS was associated with down-regulation of cyclin E. Our results thus suggest that sorafenib inhibits NSCLC cell growth by targeting B-RAF in cells with wild-type KRAS and C-RAF in those with mutant KRAS. | Sorafenib | B-Raf proto-oncogene, serine/threonine kinase | Homo sapiens |