Title : Environmental toxicants inhibit neuronal Jak tyrosine kinase by mitochondrial disruption.

Pub. Date : 2009 Jul

PMID : 19635391

1 Functional Relationships(s)
Compound Name
Protein Name
1 Exposure of BE(2)-C cells to the heavy metals CdCl(2) and HgCl(2) and to the mitochondrial complex I inhibitor rotenone inhibited interleukin-6, interferon-gamma and ciliary neurotrophic factor-mediated Jak/STAT signaling, reduced Jak1 and Jak2 auto-phosphorylation and induced Jak tyrosine nitration. Tyrosine interferon gamma Homo sapiens