Title : The regulation of vascular endothelial growth factor-induced microvascular permeability requires Rac and reactive oxygen species.

Pub. Date : 2009 Sep 18

PMID : 19633358






2 Functional Relationships(s)
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1 Additionally, treatment with VEGF caused ROS-dependent tyrosine phosphorylation of both vascular-endothelial (VE)-cadherin and beta-catenin. Tyrosine cadherin 5 Homo sapiens
2 Collectively, these data suggest that VEGF leads to a Rac-mediated generation of ROS, which, in turn, elevates the tyrosine phosphorylation of VE-cadherin and beta-catenin, ultimately regulating adherens junction integrity. Tyrosine cadherin 5 Homo sapiens