Title : Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities.

Pub. Date : 2009 Sep 3

PMID : 19619545






8 Functional Relationships(s)
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1 Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities. Ribavirin mechanistic target of rapamycin kinase Homo sapiens
2 Here, we identified a novel role of ribavirin in the communication between p53 and the mammalian target of rapamycin (mTOR) signaling. Ribavirin mechanistic target of rapamycin kinase Homo sapiens
3 Here, we identified a novel role of ribavirin in the communication between p53 and the mammalian target of rapamycin (mTOR) signaling. Ribavirin mechanistic target of rapamycin kinase Homo sapiens
4 Ribavirin activates p53 by stimulating mTOR and promoting the interaction between mTOR and p53. Ribavirin mechanistic target of rapamycin kinase Homo sapiens
5 Ribavirin activates p53 by stimulating mTOR and promoting the interaction between mTOR and p53. Ribavirin mechanistic target of rapamycin kinase Homo sapiens
6 Furthermore, ribavirin-induced activation of mTOR and p53 enhances IFN-dependent signaling for the IFN-alpha/ribavirin combined treatment. Ribavirin mechanistic target of rapamycin kinase Homo sapiens
7 Furthermore, ribavirin-induced activation of mTOR and p53 enhances IFN-dependent signaling for the IFN-alpha/ribavirin combined treatment. Ribavirin mechanistic target of rapamycin kinase Homo sapiens
8 We conclude that ribavirin enhances activities of mTOR and p53, which may account for its antiviral and antitumor effects. Ribavirin mechanistic target of rapamycin kinase Homo sapiens