Pub. Date : 2009 Oct 1
PMID : 19616567
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Taurine prevents arsenic-induced cardiac oxidative stress and apoptotic damage: role of NF-kappa B, p38 and JNK MAPK pathway. | Arsenic | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Arsenic also markedly increased the activity of p38 and JNK MAPKs, but not ERK to that extent. | Arsenic | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Pre-treatment with SP600125 (JNK inhibitor) and SB203580 (p38 MAPK inhibitor) attenuated NF-kappaB and IKK phosphorylation indicating that p38 and JNK MAPKs are mainly involved in arsenic-induced NF-kappaB activation. | Arsenic | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Taurine treatment suppressed these apoptotic actions, suggesting that its protective role in arsenic-induced cardiomyocyte apoptosis is mediated by attenuation of p38 and JNK MAPK signaling pathways. | Arsenic | mitogen-activated protein kinase 8 | Homo sapiens |