Title : [Effects of genistein on interleukin-1beta and tumor necrosis factor-alpha secreted by fibroblast-like synoviocytes isolated from type II collagen-induced arthritis rats].

Pub. Date : 2009 Jul

PMID : 19615317






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 OBJECTIVE: To investigate the effects of genistein (Gen) on interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) secreted by fibroblast-like synoviocytes (FLSs) of rats with type II collagen-induced arthritis (CIA). Genistein interleukin 1 beta Rattus norvegicus
2 After administration of different concentrations of Gen (100, 200, 400 micromol/L), the contents of IL-1beta and TNF-alpha in supernatants of FLSs were decreased dose-dependently. Genistein interleukin 1 beta Rattus norvegicus
3 CONCLUSION: Genistein can suppress the secretion of TNF-alpha and IL-1beta in FLSs dose-dependently, which may be one of the mechanisms for genistein in inhibiting the arthromeningitis of CIA rats. Genistein interleukin 1 beta Rattus norvegicus
4 CONCLUSION: Genistein can suppress the secretion of TNF-alpha and IL-1beta in FLSs dose-dependently, which may be one of the mechanisms for genistein in inhibiting the arthromeningitis of CIA rats. Genistein interleukin 1 beta Rattus norvegicus