PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19615317-1 2009 OBJECTIVE: To investigate the effects of genistein (Gen) on interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) secreted by fibroblast-like synoviocytes (FLSs) of rats with type II collagen-induced arthritis (CIA). Genistein 41-50 interleukin 1 beta Rattus norvegicus 60-77 19615317-9 2009 After administration of different concentrations of Gen (100, 200, 400 micromol/L), the contents of IL-1beta and TNF-alpha in supernatants of FLSs were decreased dose-dependently. Genistein 52-55 interleukin 1 beta Rattus norvegicus 100-108 19615317-10 2009 CONCLUSION: Genistein can suppress the secretion of TNF-alpha and IL-1beta in FLSs dose-dependently, which may be one of the mechanisms for genistein in inhibiting the arthromeningitis of CIA rats. Genistein 12-21 interleukin 1 beta Rattus norvegicus 66-74 19615317-10 2009 CONCLUSION: Genistein can suppress the secretion of TNF-alpha and IL-1beta in FLSs dose-dependently, which may be one of the mechanisms for genistein in inhibiting the arthromeningitis of CIA rats. Genistein 140-149 interleukin 1 beta Rattus norvegicus 66-74