Title : Overproduction of geranylgeraniol by metabolically engineered Saccharomyces cerevisiae.

Pub. Date : 2009 Sep

PMID : 19592534






1 Functional Relationships(s)
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1 Overexpression of the hydroxymethylglutaryl-coenzyme A reductase (HMG1) gene, which encodes the major rate-limiting enzyme of the mevalonate pathway, resulted in overproduction of squalene (191.9 mg liter(-1)) rather than GGOH (0.2 mg liter(-1)) in test tube cultures. Mevalonic Acid hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 Saccharomyces cerevisiae S288C