PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19592534-5 2009 Overexpression of the hydroxymethylglutaryl-coenzyme A reductase (HMG1) gene, which encodes the major rate-limiting enzyme of the mevalonate pathway, resulted in overproduction of squalene (191.9 mg liter(-1)) rather than GGOH (0.2 mg liter(-1)) in test tube cultures. Mevalonic Acid 130-140 hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 Saccharomyces cerevisiae S288C 66-70