Title : Rapid and enantioselective assembly of the lycorine framework using chemoenzymatic techniques.

Pub. Date : 2009 Aug 6

PMID : 19591492






1 Functional Relationships(s)
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1 The pentacyclic framework associated with the alkaloid (-)-lycorine (1) can be assembled in as few as six steps from the enantiomerically pure cis-1,2-dihydrocatechol 3 which is itself readily available on a large scale through the whole-cell biotransformation of bromobenzene. Alkaloids suppressor of cytokine signaling 1 Homo sapiens