Protein Name suppressor of cytokine signaling 1
Organism Homo sapiens
Gene ID 8651
Gene Symbol


UniProt O15524 (SOCS1_HUMAN), Q4JHT5 (Q4JHT5_HUMAN)
Relationships Total Number of functionally related compound(s) : 658
Total Number of Articles : 513

suppressor of cytokine signaling 1

Gene Summary

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]

  • suppressor of cytokine signaling 1
  • JAK binding protein
  • STAT induced SH3 protein 1
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