Protein Name | suppressor of cytokine signaling 1 |
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Organism | Homo sapiens |
Gene ID | 8651 |
Gene Symbol | SOCS1 |
UniProt | O15524 (SOCS1_HUMAN), Q4JHT5 (Q4JHT5_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
658
Total Number of Articles : 513 |
Description |
suppressor of cytokine signaling 1 |
Gene Summary |
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008] |
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