Pub. Date : 2009 Sep
PMID : 19578043
14 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We previously reported that (-)-epigallocatechin gallate (EGCG) in green tea alters plasma membrane organization and causes internalization of epidermal growth factor receptor (EGFR), resulting in the suppression of colon cancer cell growth. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 2 | We previously reported that (-)-epigallocatechin gallate (EGCG) in green tea alters plasma membrane organization and causes internalization of epidermal growth factor receptor (EGFR), resulting in the suppression of colon cancer cell growth. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 3 | We previously reported that (-)-epigallocatechin gallate (EGCG) in green tea alters plasma membrane organization and causes internalization of epidermal growth factor receptor (EGFR), resulting in the suppression of colon cancer cell growth. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 4 | We previously reported that (-)-epigallocatechin gallate (EGCG) in green tea alters plasma membrane organization and causes internalization of epidermal growth factor receptor (EGFR), resulting in the suppression of colon cancer cell growth. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 5 | In the present study, we investigated the detailed mechanism underlying EGCG-induced downregulation of EGFR in SW480 colon cancer cells. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 6 | Prolonged exposure to EGCG caused EGFR degradation. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 7 | In addition, EGCG induced phosphorylation of p38 mitogen-activated protein kinase (MAPK), a stress-inducible kinase believed to negatively regulate tumorigenesis, and the inhibition of p38 MAPK by SB203580, a specific p38 MAPK inhibitor, or the gene silencing using p38 MAPK-small interfering RNA (siRNA) suppressed the internalization and subsequent degradation of EGFR induced by EGCG. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 8 | EGFR underwent a gel mobility shift upon treatment with EGCG and this was canceled by SB203580, indicating that EGCG causes EGFR phosphorylation via p38 MAPK. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 9 | EGFR underwent a gel mobility shift upon treatment with EGCG and this was canceled by SB203580, indicating that EGCG causes EGFR phosphorylation via p38 MAPK. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 10 | EGFR underwent a gel mobility shift upon treatment with EGCG and this was canceled by SB203580, indicating that EGCG causes EGFR phosphorylation via p38 MAPK. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 11 | EGFR underwent a gel mobility shift upon treatment with EGCG and this was canceled by SB203580, indicating that EGCG causes EGFR phosphorylation via p38 MAPK. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 12 | Moreover, EGCG caused phosphorylation of EGFR at Ser1046/1047, a site that is critical for its downregulation and this was also suppressed by SB203580 or siRNA of p38 MAPK. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 13 | Taken together, our results strongly suggest that phosphorylation of EGFR at serine 1046/1047 via activation of p38 MAPK plays a pivotal role in EGCG-induced downregulation of EGFR in colon cancer cells. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |
| 14 | Taken together, our results strongly suggest that phosphorylation of EGFR at serine 1046/1047 via activation of p38 MAPK plays a pivotal role in EGCG-induced downregulation of EGFR in colon cancer cells. | epigallocatechin gallate | epidermal growth factor receptor | Homo sapiens |