Title : Thrombin stimulates smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.

Pub. Date : 2009 Jul 31

PMID : 19574550






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Thrombin-stimulated upregulation of the transcription factor myocardin and smooth muscle myosin heavy chain, and both were inhibited by hirudin or the RhoA inhibitor Y27632. Y 27632 coagulation factor II, thrombin Homo sapiens
2 Thrombin-induced enhancement of smooth muscle outgrowth colony formation was inhibited by hirudin, Y27632, and an antibody against protease-activated receptor-1. Y 27632 coagulation factor II, thrombin Homo sapiens