Title : Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors.

Pub. Date : 2009 Sep 23

PMID : 19572644






1 Functional Relationships(s)
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1 Last, we identified the b-Raf inhibitor sorafenib as a potent low nanomolar inhibitor of p38alpha and used protein X-ray crystallography to confirm a unique binding mode to the inactive kinase conformation. Sorafenib B-Raf proto-oncogene, serine/threonine kinase Homo sapiens