Title : Molecular basis of the acceleration of the GDP-GTP exchange of human ras homolog enriched in brain by human translationally controlled tumor protein.

Pub. Date : 2009 Aug 28

PMID : 19570981






1 Functional Relationships(s)
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1 To investigate the underlying mechanism, we built structure models of GDP- and GTP-bound hRheb in complexes with hTCTP and performed molecular dynamics simulations of the models, which predict key residues involved in the interactions and region of hRheb undergoing conformational change during the GDP-GTP exchange. Guanosine Diphosphate Ras homolog, mTORC1 binding Homo sapiens