Pub. Date : 2009 Jul 15
PMID : 19567673
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Topotecan is a substrate of the ATP-binding cassette transporters P-glycoprotein (P-gp/MDR1) and breast cancer resistance protein (BCRP). | Topotecan | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 2 | Topotecan is a substrate of the ATP-binding cassette transporters P-glycoprotein (P-gp/MDR1) and breast cancer resistance protein (BCRP). | Topotecan | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 3 | Preferential active transport of topotecan lactone over topotecan carboxylate was shown in vivo by vCSF lactone-to-carboxylate area under the curve ratios for wild-type, Mdr1a/b(-/-), Bcrp1(-/-), and Mdr1a/b(-/-)Bcrp1(-/-) mice of 5.69 +/- 0.83, 3.85 +/- 0.64, 3.61 +/- 0.46, and 0.78 +/- 0.19, respectively. | Topotecan | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 4 | Preferential active transport of topotecan lactone over topotecan carboxylate was shown in vivo by vCSF lactone-to-carboxylate area under the curve ratios for wild-type, Mdr1a/b(-/-), Bcrp1(-/-), and Mdr1a/b(-/-)Bcrp1(-/-) mice of 5.69 +/- 0.83, 3.85 +/- 0.64, 3.61 +/- 0.46, and 0.78 +/- 0.19, respectively. | Topotecan | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 5 | Our results suggest that Bcrp1 and P-gp transport topotecan into vCSF and out of brain parenchyma through the blood-brain barrier. | Topotecan | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |