Pub. Date : 2009 Jan
PMID : 19563028
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Arsenic trioxide inhibits cell growth in imatinib-resistant bcr-abl mutant cell lines in vitro]. | Arsenic Trioxide | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 2 | OBJECTIVE: To explore the effect of arsenic trioxide (As2O3) on the growth inhibition of imatinib (IM)-resistant bcr-abl mutant cell lines in vitro. | Arsenic Trioxide | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 3 | OBJECTIVE: To explore the effect of arsenic trioxide (As2O3) on the growth inhibition of imatinib (IM)-resistant bcr-abl mutant cell lines in vitro. | Arsenic Trioxide | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 4 | For the 5 bcr-abl mutants frequently happened in CML patients, As2O3 significantly inhibited the expression of bcr-abl fusion protein and phosphorylated CRKL and induced apoptosis in a dose-dependent manner as compared with that for 32Dp210. | Arsenic Trioxide | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 5 | For the 5 bcr-abl mutants frequently happened in CML patients, As2O3 significantly inhibited the expression of bcr-abl fusion protein and phosphorylated CRKL and induced apoptosis in a dose-dependent manner as compared with that for 32Dp210. | Arsenic Trioxide | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 6 | CONCLUSION: As2O3 remarkably inhibits cell growth and induces apoptosis of IM-resistant bcr-abl mutant cell lines in vitro, suggesting that it might be a potential therapeutic agent for IM-resistant CML patients. | Arsenic Trioxide | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |