Pub. Date : 2009 Sep 15
PMID : 19559082
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Polycyclic aromatic hydrocarbons such as benzo(a)pyrene (BaP) are toxic environmental contaminants known to regulate gene expression through activation of the aryl hydrocarbon receptor (AhR). | Benzo(a)pyrene | aryl hydrocarbon receptor | Homo sapiens |
| 2 | Polycyclic aromatic hydrocarbons such as benzo(a)pyrene (BaP) are toxic environmental contaminants known to regulate gene expression through activation of the aryl hydrocarbon receptor (AhR). | Benzo(a)pyrene | aryl hydrocarbon receptor | Homo sapiens |
| 3 | Polycyclic aromatic hydrocarbons such as benzo(a)pyrene (BaP) are toxic environmental contaminants known to regulate gene expression through activation of the aryl hydrocarbon receptor (AhR). | Benzo(a)pyrene | aryl hydrocarbon receptor | Homo sapiens |
| 4 | Polycyclic aromatic hydrocarbons such as benzo(a)pyrene (BaP) are toxic environmental contaminants known to regulate gene expression through activation of the aryl hydrocarbon receptor (AhR). | Benzo(a)pyrene | aryl hydrocarbon receptor | Homo sapiens |
| 5 | NCF1 induction in BaP-treated human macrophages was prevented by targeting AhR, through its chemical inhibition or small interference RNA-mediated down-modulation of its expression. | Benzo(a)pyrene | aryl hydrocarbon receptor | Homo sapiens |
| 6 | BaP moreover induced activity of the NCF1 promoter sequence, containing a consensus AhR-related xenobiotic-responsive element (XRE), and electrophoretic mobility shift assays and chromatin immunoprecipitation experiments indicated that BaP-triggered binding of AhR to this XRE. | Benzo(a)pyrene | aryl hydrocarbon receptor | Homo sapiens |
| 7 | BaP moreover induced activity of the NCF1 promoter sequence, containing a consensus AhR-related xenobiotic-responsive element (XRE), and electrophoretic mobility shift assays and chromatin immunoprecipitation experiments indicated that BaP-triggered binding of AhR to this XRE. | Benzo(a)pyrene | aryl hydrocarbon receptor | Homo sapiens |
| 8 | This BaP priming effect toward NADPH oxidase activity was inhibited by the NADPH oxidase specific inhibitor apocynin and the chemical AhR inhibitor alpha-naphtoflavone. | Benzo(a)pyrene | aryl hydrocarbon receptor | Homo sapiens |
| 9 | These results indicated that BaP induced NCF1/p47(phox) expression and subsequently enhanced superoxide anion production in PMA-treated human macrophages, in an AhR-dependent manner; such an NCF1/NADPH oxidase regulation by polycyclic aromatic hydrocarbons may participate in deleterious effects toward human health triggered by these environmental contaminants, including atherosclerosis and smoking-related diseases. | Benzo(a)pyrene | aryl hydrocarbon receptor | Homo sapiens |