Title : Design, synthesis, and biological evaluation of 3,4,5-trimethoxyphenyl acrylamides as antinarcotic agents.

Pub. Date : 2010 Feb

PMID : 19555163






1 Functional Relationships(s)
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1 When tested for biological activity, compounds 1d-f exhibited strong inhibitory effects on the morphine withdrawal syndrome in mice due to their high binding affinities with serotonergic 5-HT1A receptors. Morphine 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus