Pub. Date : 2010 Oct
PMID : 19554262
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nelfinavir induces mitochondria protection by ERK1/2-mediated mcl-1 stabilization that can be overcome by sorafenib. | Nelfinavir | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 2 | In contrast to the pro-apoptotic effect of nelfinavir on human cancer cells, we noticed a significant upregulation of the anti-apoptotic mitochondrial membrane protein mcl-1 by nelfinavir, resulting in a mitochondria-independent induction of apoptosis. | Nelfinavir | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 3 | The combination of nelfinavir with sorafenib, a clinically applied inhibitor of the RAS/RAF/ERK1/2 pathway, inhibited nelfinavir-induced ERK1/2 activation and mcl-1 protein upregulation. | Nelfinavir | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |