Title : Resveratrol alters proliferative responses and apoptosis in human activated B lymphocytes in vitro.

Pub. Date : 2009 Aug

PMID : 19549761






3 Functional Relationships(s)
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1 Expression of Bcl-2 and caspase-3 activation increased in B cells treated with 10 mumol/L resveratrol compared with mitogen alone (P < 0.01), and trends for dose-responsive increases in Bcl-2 expression and caspase-3 activation were observed (P-trend < 0.0001). Resveratrol BCL2 apoptosis regulator Homo sapiens
2 Expression of Bcl-2 and caspase-3 activation increased in B cells treated with 10 mumol/L resveratrol compared with mitogen alone (P < 0.01), and trends for dose-responsive increases in Bcl-2 expression and caspase-3 activation were observed (P-trend < 0.0001). Resveratrol BCL2 apoptosis regulator Homo sapiens
3 These data show that human B lymphocyte proliferation and apoptosis are modified by physiological concentrations of resveratrol and suggest that exposure of human B cells to resveratrol may increase survival by upregulating Bcl-2. Resveratrol BCL2 apoptosis regulator Homo sapiens