Pub. Date : 2009 Jul 15
PMID : 19540766
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nucleoside-amino acid conjugates have been employed to inhibit the ribonucleolytic activity of ribonuclease A (RNase A) and affect the protonation/deprotonation equilibrium of its active site histidine residues. | Histidine | ribonuclease A family member 1, pancreatic | Homo sapiens |
| 2 | Nucleoside-amino acid conjugates have been employed to inhibit the ribonucleolytic activity of ribonuclease A (RNase A) and affect the protonation/deprotonation equilibrium of its active site histidine residues. | Histidine | ribonuclease A family member 1, pancreatic | Homo sapiens |
| 3 | The nucleoside-serine conjugate occupies the active site of RNase A and preferential perturbs the pK(a) value of His-119 by its "free amino group" as found from (1)H NMR studies. | Histidine | ribonuclease A family member 1, pancreatic | Homo sapiens |
| 4 | Docking studies revealed that the free amino groups of the most active compounds are within hydrogen bonding distance of His-119 in inhibitor-RNase A complexes. | Histidine | ribonuclease A family member 1, pancreatic | Homo sapiens |