Pub. Date : 2009 Aug 1
PMID : 19528373
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our group previously demonstrated a strong interaction between plasma selenium and the manganese superoxide dismutase (SOD2) gene and incident prostate cancer risk. | Selenium | superoxide dismutase 2 | Homo sapiens |
| 2 | Our group previously demonstrated a strong interaction between plasma selenium and the manganese superoxide dismutase (SOD2) gene and incident prostate cancer risk. | Selenium | superoxide dismutase 2 | Homo sapiens |
| 3 | We now hypothesized that SOD2 modifies the association between selenium level and risk of aggressive prostate cancer at diagnosis. | Selenium | superoxide dismutase 2 | Homo sapiens |
| 4 | There was evidence of an interaction between SOD2 and selenium levels such that among men with the AA genotype, higher selenium levels were associated with a reduced risk of presenting with aggressive disease (RR = 0.60; 95% CI, 0.32 to 1.12), whereas among men with a V allele, higher selenium levels were associated with an increased risk of aggressive disease (for VV or VA men, RR = 1.82; 95% CI, 1.27 to 2.61; P for interaction = .007). | Selenium | superoxide dismutase 2 | Homo sapiens |
| 5 | There was evidence of an interaction between SOD2 and selenium levels such that among men with the AA genotype, higher selenium levels were associated with a reduced risk of presenting with aggressive disease (RR = 0.60; 95% CI, 0.32 to 1.12), whereas among men with a V allele, higher selenium levels were associated with an increased risk of aggressive disease (for VV or VA men, RR = 1.82; 95% CI, 1.27 to 2.61; P for interaction = .007). | Selenium | superoxide dismutase 2 | Homo sapiens |