Title : Antitumor activity with CYP17 blockade indicates that castration-resistant prostate cancer frequently remains hormone driven.

Pub. Date : 2009 Jun 15

PMID : 19509232






2 Functional Relationships(s)
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1 Abiraterone acetate is a potent, selective, and orally bioavailable small molecule inhibitor of CYP17, an enzyme that catalyzes two key serial reactions (17 alpha hydroxylase and 17,20 lyase) in androgen and estrogen biosynthesis. Abiraterone Acetate cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 Biomarker studies, including the analysis of ETS gene fusion status, on patients treated with abiraterone acetate may allow enrichment of patients with a sensitive phenotype in future studies of therapeutics targeting CYP17. Abiraterone Acetate cytochrome P450 family 17 subfamily A member 1 Homo sapiens