Pub. Date : 2009 Jul 1
PMID : 19502798
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show that rapid AJ/TJ disassembly triggered by extracellular calcium depletion of T84 and SK-CO15 cell monolayers was accompanied by activation (phosphorylation) of JNK, and prevented by pharmacological inhibitors of JNK. | Calcium | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | We show that rapid AJ/TJ disassembly triggered by extracellular calcium depletion of T84 and SK-CO15 cell monolayers was accompanied by activation (phosphorylation) of JNK, and prevented by pharmacological inhibitors of JNK. | Calcium | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | JNK1 but not JNK2 was found to colocalize with intercellular junctions, and siRNA-mediated downregulation of JNK1 attenuated the TJ/AJ disruption caused by calcium depletion. | Calcium | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | JNK1 but not JNK2 was found to colocalize with intercellular junctions, and siRNA-mediated downregulation of JNK1 attenuated the TJ/AJ disruption caused by calcium depletion. | Calcium | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | JNK inhibition also blocked formation of characteristic contractile F-actin rings in calcium-depleted epithelial cells, suggesting that JNK regulates junctions by remodeling the actin cytoskeleton. | Calcium | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | JNK inhibition also blocked formation of characteristic contractile F-actin rings in calcium-depleted epithelial cells, suggesting that JNK regulates junctions by remodeling the actin cytoskeleton. | Calcium | mitogen-activated protein kinase 8 | Homo sapiens |
| 7 | In this role JNK acts downstream of the actin-reorganizing Rho-dependent kinase (ROCK), since ROCK inhibition abrogated JNK phosphorylation and TJ/AJ disassembly after calcium depletion. | Calcium | mitogen-activated protein kinase 8 | Homo sapiens |