Title : Dual actions of progesterone on uterine leiomyoma correlate with the ratio of progesterone receptor A:B.

Pub. Date : 2009 Aug

PMID : 19499404






2 Functional Relationships(s)
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1 The present study was conducted to elucidate whether progesterone affects IGF-I mRNA through progesterone receptor B(PRB) mRNA in leiomyoma. Progesterone RB transcriptional corepressor 1 Homo sapiens
2 CONCLUSION: The progesterone may down-regulate IGF-I expression through PRB, and PRA appears to inhibit this function of progesterone by inhibiting the transcription of PRB; thus, the action of progesterone on leiomyoma growth may depend on different ratios of PRA and PRB. Progesterone RB transcriptional corepressor 1 Homo sapiens