Title : Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis.

Pub. Date : 2009 Jun 15

PMID : 19494326






1 Functional Relationships(s)
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1 We provide evidence that metformin attenuates the induction of EAE by restricting the infiltration of mononuclear cells into the CNS, down-regulating the expression of proinflammatory cytokines (IFN-gamma, TNF-alpha, IL-6, IL-17, and inducible NO synthase (iNOS)), cell adhesion molecules, matrix metalloproteinase 9, and chemokine (RANTES). Metformin interleukin 6 Homo sapiens