Pub. Date : 2009 May
PMID : 19493891
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In contrast to the sustained phosphorylation of c-Jun NH(2)-terminal kinase (JNK) and p38, NaF exposure induced a biphasic phosphorylation of extracellular signal-regulated protein kinase (ERK). | Sodium Fluoride | mitogen-activated protein kinase 8 | Mus musculus |
| 2 | NaF-induced apoptosis was markedly suppressed by treatment with the JNK inhibitor, SP600125, and mildly suppressed by the MAPK/ERK kinase inhibitor, U0126. | Sodium Fluoride | mitogen-activated protein kinase 8 | Mus musculus |
| 3 | Thus, exposure to NaF induces apoptosis in odontoblast-like cells, depending on JNK and, less significantly, ERK pathways. | Sodium Fluoride | mitogen-activated protein kinase 8 | Mus musculus |