Title : BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing.

Pub. Date : 2009 Aug

PMID : 19483105






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Overexpression of cellular FLICE-like inhibitory protein (c-FLIP-s) or knockdown of CD95 suppressed the lethality of the sorafenib/HDACI combination (sorafenib + HDACI). Sorafenib CASP8 and FADD like apoptosis regulator Homo sapiens
2 Overexpression of cellular FLICE-like inhibitory protein (c-FLIP-s) or knockdown of CD95 suppressed the lethality of the sorafenib/HDACI combination (sorafenib + HDACI). Sorafenib CASP8 and FADD like apoptosis regulator Homo sapiens
3 Overexpression of cellular FLICE-like inhibitory protein (c-FLIP-s) or knockdown of CD95 suppressed the lethality of the sorafenib/HDACI combination (sorafenib + HDACI). Sorafenib CASP8 and FADD like apoptosis regulator Homo sapiens
4 Overexpression of cellular FLICE-like inhibitory protein (c-FLIP-s) or knockdown of CD95 suppressed the lethality of the sorafenib/HDACI combination (sorafenib + HDACI). Sorafenib CASP8 and FADD like apoptosis regulator Homo sapiens