Title : Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms.

Pub. Date : 2009 Aug

PMID : 19483104






2 Functional Relationships(s)
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1 In SW480 cells, sorafenib + vorinostat increased CD95 plasma membrane levels and promoted death-inducing signal complex (DISC) formation, and drug toxicity was blocked by knockdown of CD95 or overexpression of cellular FLICE-like inhibitory protein (c-FLIP-s). Sorafenib CASP8 and FADD like apoptosis regulator Homo sapiens
2 In SW480 cells, sorafenib + vorinostat increased CD95 plasma membrane levels and promoted death-inducing signal complex (DISC) formation, and drug toxicity was blocked by knockdown of CD95 or overexpression of cellular FLICE-like inhibitory protein (c-FLIP-s). Sorafenib CASP8 and FADD like apoptosis regulator Homo sapiens