Title : Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450s.

Pub. Date : 2009 Oct 7

PMID : 19482014






1 Functional Relationships(s)
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1 Formation of reactive intermediates of chlorpromazine and thioridazine was primarily mediated by heterologously expressed recombinant CYP2D6, and to a less extent, CYP1A2. Thioridazine cytochrome P450 family 1 subfamily A member 2 Homo sapiens