Title : TSH induces co-localization of TSH receptor and Na/K-ATPase in human erythrocytes.

Pub. Date : 2009 Jul

PMID : 19466745






3 Functional Relationships(s)
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1 TSH induces co-localization of TSH receptor and Na/K-ATPase in human erythrocytes. Thyrotropin thyroid stimulating hormone receptor Homo sapiens
2 We found that TSH receptor and Na/K-ATPase are localized on the membranes of both erythrocytes and erythrocyte ghosts; TSH receptor responds to TSH treatment by increasing intracellular cAMP levels from two to tenfold. Thyrotropin thyroid stimulating hormone receptor Homo sapiens
3 In ghost membranes TSH treatment enhances up to three fold co-localization of TSHR with Na/K-ATPase and co-immunoprecipitation confirms their direct physical interaction. Thyrotropin thyroid stimulating hormone receptor Homo sapiens