Title : Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530-resistant tumors.

Pub. Date : 2009 May 15

PMID : 19451593






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 AZD0530-resistant tumors showed activation of bypass pathways including MEK and phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin, raising the possibility that MEK, mammalian target of rapamycin (mTOR), or PI3K inhibitors may augment Src inhibitor efficacy. saracatinib mitogen-activated protein kinase kinase 7 Homo sapiens
2 AZD0530-resistant tumors showed activation of bypass pathways including MEK and phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin, raising the possibility that MEK, mammalian target of rapamycin (mTOR), or PI3K inhibitors may augment Src inhibitor efficacy. saracatinib mitogen-activated protein kinase kinase 7 Homo sapiens