Pub. Date : 2009 Jul
PMID : 19440933
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. | Quercetin | catenin beta 1 | Homo sapiens |
| 2 | The aim of this study was to investigate the effects of quercetin on the growth of the colon carcinoma cell line and the regulation effect of quercetin on the Wnt/beta-catenin signaling pathway. | Quercetin | catenin beta 1 | Homo sapiens |
| 3 | The regulation effect of quercetin on the Wnt/beta-catenin signaling transcription was investigated by using this reporter gene model. | Quercetin | catenin beta 1 | Homo sapiens |
| 4 | Quercetin downregulated transcriptional activity of beta-catenin/Tcf in SW480 cells transiently transfected with the TCF-4 reporter gene. | Quercetin | catenin beta 1 | Homo sapiens |
| 5 | Within 24 hours of treatment, a 160-mumol/L concentration of quercetin reduced beta-catenin/Tcf transcriptional activity by about 18-fold. | Quercetin | catenin beta 1 | Homo sapiens |
| 6 | CONCLUSION: The results indicate that the molecular mechanism underlying the antitumor effect of quercetin in SW480 colon cancer cells is related to the inhibition of expression of cyclin D(1) and survivin as well as the Wnt/beta-catenin signaling pathway. | Quercetin | catenin beta 1 | Homo sapiens |