Title : Metformin induces unique biological and molecular responses in triple negative breast cancer cells.

Pub. Date : 2009 Jul 1

PMID : 19440038






2 Functional Relationships(s)
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1 At the molecular level, metformin increases P-AMPK, reduces P-EGFR, EGFR, P-MAPK, P-Src, cyclin D1 and cyclin E (but not cyclin A or B, p27 or p21), and induces PARP cleavage in a dose- and time-dependent manner. Metformin epidermal growth factor receptor Homo sapiens
2 At the molecular level, metformin increases P-AMPK, reduces P-EGFR, EGFR, P-MAPK, P-Src, cyclin D1 and cyclin E (but not cyclin A or B, p27 or p21), and induces PARP cleavage in a dose- and time-dependent manner. Metformin epidermal growth factor receptor Homo sapiens