Title : (-)-Epigallocatechin-3-gallate inhibits Hsp90 function by impairing Hsp90 association with cochaperones in pancreatic cancer cell line Mia Paca-2.

Pub. Date : 2009 Jul-Aug

PMID : 19438225






1 Functional Relationships(s)
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1 Western blotting analysis demonstrated that (-)-EGCG induced downregulation of oncogenic Hsp90 client proteins by approximately 70-95%, including Akt, Cdk4, Raf-1, Her-2, and pERK. epigallocatechin gallate erb-b2 receptor tyrosine kinase 2 Homo sapiens