Title : Functional analysis of long-chain acyl-CoA synthetase 1 in 3T3-L1 adipocytes.

Pub. Date : 2009 Jul 3

PMID : 19429676






3 Functional Relationships(s)
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1 However, ACSL1 kd adipocytes displayed a 7-fold increase in basal and a approximately 15% increase in forskolin-stimulated fatty acid efflux without any change in glycerol release, indicating a role for the protein in fatty acid reesterification following lipolysis. Fatty Acids acyl-CoA synthetase long-chain family member 1 Mus musculus
2 However, ACSL1 kd adipocytes displayed a 7-fold increase in basal and a approximately 15% increase in forskolin-stimulated fatty acid efflux without any change in glycerol release, indicating a role for the protein in fatty acid reesterification following lipolysis. Fatty Acids acyl-CoA synthetase long-chain family member 1 Mus musculus
3 These findings identify a primary role of ACSL1 in adipocytes not in control of lipid influx, as previously considered, but in lipid efflux and fatty acid-induced insulin resistance. Fatty Acids acyl-CoA synthetase long-chain family member 1 Mus musculus