| Protein Name | acyl-CoA synthetase long-chain family member 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 14081 |
| Gene Symbol | Acsl1 |
| UniProt | P41216 (ACSL1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
182
Total Number of Articles : 179 |
Description |
acyl-CoA synthetase long-chain family member 1 |
| Gene Summary |
The protein encoded by this gene belongs to a family of acyl coenzyme A synthetase proteins, which convert long chain fatty acids to acyl CoA products via an ATP-dependent pathway. This enzyme is enriched in heart, liver and adipose tissue, where it functions in lipid synthesis and mitochondrial and peroxisomal beta-oxidation. In addition, it is expressed in monocytes and macrophages where it appears to have a functionally distinct role in mediating inflammatory and innate immune responses. A pseudogene of this gene is found on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] |
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