Protein Name acyl-CoA synthetase long-chain family member 1
Organism Mus musculus
Gene ID 14081
Gene Symbol


UniProt P41216 (ACSL1_MOUSE)
Relationships Total Number of functionally related compound(s) : 182
Total Number of Articles : 179

acyl-CoA synthetase long-chain family member 1

Gene Summary

The protein encoded by this gene belongs to a family of acyl coenzyme A synthetase proteins, which convert long chain fatty acids to acyl CoA products via an ATP-dependent pathway. This enzyme is enriched in heart, liver and adipose tissue, where it functions in lipid synthesis and mitochondrial and peroxisomal beta-oxidation. In addition, it is expressed in monocytes and macrophages where it appears to have a functionally distinct role in mediating inflammatory and innate immune responses. A pseudogene of this gene is found on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

  • long-chain-fatty-acid--CoA ligase 1
  • acetate-CoA ligase
  • acetyl-CoA synthetase
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