Title : Gene expression profiling in the liver and lung of perfluorooctane sulfonate-exposed mouse fetuses: comparison to changes induced by exposure to perfluorooctanoic acid.

Pub. Date : 2009 Jun

PMID : 19429403






2 Functional Relationships(s)
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1 PFOS-dependent changes were primarily related to activation of PPAR alpha. perfluorooctane sulfonic acid peroxisome proliferator activated receptor alpha Mus musculus
2 Given that PPAR alpha signaling is required for neonatal mortality in PFOA-treated mice but not those exposed to PFOS, the neonatal mortality observed for PFOS may reflect functional deficits related to the physical properties of the chemical rather than to transcript alterations. perfluorooctane sulfonic acid peroxisome proliferator activated receptor alpha Mus musculus