Pub. Date : 2009 Jun
PMID : 19417717
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of oral administration of S-1 on the pharmacokinetics of SN-38, irinotecan active metabolite, in patients with advanced colorectal cancer. | Irinotecan | proteasome 26S subunit, non-ATPase 1 | Homo sapiens |
| 2 | Effects of oral administration of S-1 on the pharmacokinetics of SN-38, irinotecan active metabolite, in patients with advanced colorectal cancer. | Irinotecan | proteasome 26S subunit, non-ATPase 1 | Homo sapiens |
| 3 | The objective of this study was to describe the interaction between CPT-11 and S-1 in 4 patients with colorectal cancer. | Irinotecan | proteasome 26S subunit, non-ATPase 1 | Homo sapiens |
| 4 | Coadministration of S-1 changed the pharmacokinetic behavior of CPT-11 and its metabolites. | Irinotecan | proteasome 26S subunit, non-ATPase 1 | Homo sapiens |
| 5 | In particular, maximum plasma concentration (Cmax) and area under the plasma concentration curve (AUC) of 7-ethyl-10-hydroxycampothecin (SN-38) was markedly decreased by coadministration of S-1. | Irinotecan | proteasome 26S subunit, non-ATPase 1 | Homo sapiens |
| 6 | In particular, maximum plasma concentration (Cmax) and area under the plasma concentration curve (AUC) of 7-ethyl-10-hydroxycampothecin (SN-38) was markedly decreased by coadministration of S-1. | Irinotecan | proteasome 26S subunit, non-ATPase 1 | Homo sapiens |
| 7 | For SN-38, the median ratio of Cmax and AUC with S-1 to those without S-1 was median 0.34 (range 0.24-0.78) and 0.56 (range 0.23-0.68), respectively. | Irinotecan | proteasome 26S subunit, non-ATPase 1 | Homo sapiens |
| 8 | For SN-38, the median ratio of Cmax and AUC with S-1 to those without S-1 was median 0.34 (range 0.24-0.78) and 0.56 (range 0.23-0.68), respectively. | Irinotecan | proteasome 26S subunit, non-ATPase 1 | Homo sapiens |
| 9 | We conclude that the plasma concentration of SN-38 was decreased by oral administration of S-1 in patients with colorectal cancer. | Irinotecan | proteasome 26S subunit, non-ATPase 1 | Homo sapiens |