PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19417717-0	2009	Effects of oral administration of S-1 on the pharmacokinetics of SN-38, irinotecan active metabolite, in patients with advanced colorectal cancer.	Irinotecan	65-70	proteasome 26S subunit, non-ATPase 1	Homo sapiens	34-37	
19417717-0	2009	Effects of oral administration of S-1 on the pharmacokinetics of SN-38, irinotecan active metabolite, in patients with advanced colorectal cancer.	Irinotecan	72-82	proteasome 26S subunit, non-ATPase 1	Homo sapiens	34-37	
19417717-2	2009	The objective of this study was to describe the interaction between CPT-11 and S-1 in 4 patients with colorectal cancer.	Irinotecan	68-74	proteasome 26S subunit, non-ATPase 1	Homo sapiens	79-82	
19417717-3	2009	Coadministration of S-1 changed the pharmacokinetic behavior of CPT-11 and its metabolites.	Irinotecan	64-70	proteasome 26S subunit, non-ATPase 1	Homo sapiens	20-23	
19417717-4	2009	In particular, maximum plasma concentration (Cmax) and area under the plasma concentration curve (AUC) of 7-ethyl-10-hydroxycampothecin (SN-38) was markedly decreased by coadministration of S-1.	Irinotecan	106-135	proteasome 26S subunit, non-ATPase 1	Homo sapiens	190-193	
19417717-4	2009	In particular, maximum plasma concentration (Cmax) and area under the plasma concentration curve (AUC) of 7-ethyl-10-hydroxycampothecin (SN-38) was markedly decreased by coadministration of S-1.	Irinotecan	137-142	proteasome 26S subunit, non-ATPase 1	Homo sapiens	190-193	
19417717-5	2009	For SN-38, the median ratio of Cmax and AUC with S-1 to those without S-1 was median 0.34 (range 0.24-0.78) and 0.56 (range 0.23-0.68), respectively.	Irinotecan	4-9	proteasome 26S subunit, non-ATPase 1	Homo sapiens	49-52	
19417717-5	2009	For SN-38, the median ratio of Cmax and AUC with S-1 to those without S-1 was median 0.34 (range 0.24-0.78) and 0.56 (range 0.23-0.68), respectively.	Irinotecan	4-9	proteasome 26S subunit, non-ATPase 1	Homo sapiens	70-73	
19417717-7	2009	We conclude that the plasma concentration of SN-38 was decreased by oral administration of S-1 in patients with colorectal cancer.	Irinotecan	45-50	proteasome 26S subunit, non-ATPase 1	Homo sapiens	91-94