Title : Metformin decreases angiogenesis via NF-kappaB and Erk1/2/Erk5 pathways by increasing the antiangiogenic thrombospondin-1.

Pub. Date : 2009 Aug 1

PMID : 19414528






2 Functional Relationships(s)
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Protein Name
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1 After 6 months of metformin treatment, there was a significant increase in serum TSP-1 (P < 0.05) and a corresponding decrease in PAI-1 and PAI-1 activity (P < 0.01). Metformin serpin family E member 1 Homo sapiens
2 After 6 months of metformin treatment, there was a significant increase in serum TSP-1 (P < 0.05) and a corresponding decrease in PAI-1 and PAI-1 activity (P < 0.01). Metformin serpin family E member 1 Homo sapiens