Title : Probing the role of backbone hydrogen bonding in a critical beta sheet of the extracellular domain of a cys-loop receptor.

Pub. Date : 2009 May 25

PMID : 19405066






1 Functional Relationships(s)
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1 However, eliminating two proximal hydrogen bonds completely destroys receptor function; this adds further support to gating models that ascribe important roles to these beta strands of the nAChR extracellular domain.Long-range communication is essential for the function of members of the Cys-loop family of neurotransmitter-gated ion channels. Cysteine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens