Title : Differential regulation of gonadotropin-releasing hormone neuron activity and membrane properties by acutely applied estradiol: dependence on dose and estrogen receptor subtype.

Pub. Date : 2009 Apr 29

PMID : 19403828






3 Functional Relationships(s)
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1 In vivo, estradiol can inhibit or stimulate GnRH release depending on concentration and physiological state. Estradiol gonadotropin releasing hormone 1 Mus musculus
2 Without blockade of ionotropic GABA and glutamate receptors, however, 10 pm estradiol reduced firing of GnRH neurons; this was mimicked by an ERalpha agonist. Estradiol gonadotropin releasing hormone 1 Mus musculus
3 These data suggest rapid intrinsic and network modulation of GnRH neurons by estradiol is dependent on both dose and receptor subtype. Estradiol gonadotropin releasing hormone 1 Mus musculus