Title : Transcription factors in the pathogenesis of diabetic nephropathy.

Pub. Date : 2009 Apr 28

PMID : 19397838






1 Functional Relationships(s)
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1 In response to high glucose, several of these transcription factors regulate the gene encoding the profibrotic cytokine transforming growth factor beta, as well as genes for a range of other proteins implicated in inflammation and extracellular matrix turnover, including thrombospondin 1, the chemokine CCL2, osteopontin, fibronectin, decorin, plasminogen activator inhibitor 1 and aldose reductase. Glucose aldo-keto reductase family 1 member B Homo sapiens