Pub. Date : 2009 Apr
PMID : 19397439
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Suppression of NF-kappaB activity by parthenolide induces X-ray sensitivity through inhibition of split-dose repair in TP53 null prostate cancer cells. | parthenolide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | We have shown that parthenolide, a sesquiterpene lactone, is a radiation sensitizer for human CGL1 hybrid cells that have constitutively activated NF-kappaB and wild-type p53. | parthenolide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | We hypothesized that inhibition of NF-kappaB activity by parthenolide was responsible for the observed X-ray sensitization and inhibition of split-dose repair. | parthenolide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Inhibition of NF-kappaB activity by knockdown of p65 increased radiation sensitivity and completely inhibited split-dose repair in both cell lines in a nearly identical manner as parthenolide treatment alone. | parthenolide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | We propose that the suppression of radiation-induced NF-kappaB activity by parthenolide leads to X-ray sensitization through inhibition of split-dose repair in p53 null PC-3 prostate cancer cells. | parthenolide | nuclear factor kappa B subunit 1 | Homo sapiens |