Pub. Date : 1991 Nov 25
PMID : 1939245
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rap1A is a Ras-related GTP binding protein which has an amino acid sequence identical to that of Ras in the putative "effector" domain (amino acids 32-40). | Guanosine Triphosphate | RAP1A, member of RAS oncogene family | Homo sapiens |
| 2 | We observed that both Rap1A-GDP and Rap1A-guanosine 5"-3-O-(thio)triphosphate (GTP gamma S) were able to block the inhibitory effect of Ras-GAP upon channel activation. | Guanosine Triphosphate | RAP1A, member of RAS oncogene family | Homo sapiens |
| 3 | We observed that both Rap1A-GDP and Rap1A-guanosine 5"-3-O-(thio)triphosphate (GTP gamma S) were able to block the inhibitory effect of Ras-GAP upon channel activation. | Guanosine Triphosphate | RAP1A, member of RAS oncogene family | Homo sapiens |
| 4 | A Rap1A Thr35----Ala mutation which bound GTP gamma S did not prevent K+ channel inhibition by Ras-GAP, suggesting that the antagonism by wild type Rap1A involves an interaction with GAP in the effector domain. | Guanosine Triphosphate | RAP1A, member of RAS oncogene family | Homo sapiens |
| 5 | The effectiveness of Rap1A to inhibit Ras-GAP is dependent upon the amount of Ras-GAP present in the assay and can also be overcome by the addition of GTP-bound N-Ras (GC-43), suggesting a competitive mechanism is operative. | Guanosine Triphosphate | RAP1A, member of RAS oncogene family | Homo sapiens |